RNA Binding Proteins: New Concepts in Gene Regulation: 16: Sandberg, Kathryn, Mulroney,: Amazon.se: Books.
Nov 15, 2011 The fragile X protein FMRP helps make proteins at the synapse, the FMRP binds to messenger RNA in the nucleus, preventing it from being
Schumacher, Jill; Keesook Lee; Susanne Edelhoff; Robert Braun (May 1995). "Spnr, a Murine RNA-binding Protein That Is Localized to "Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays "Long-term memory consolidation: The role of RNA-binding proteins with 0, 8, fig|393124.3.peg.2573, Listeria monocytogenes FSL N3-165, RNA-binding protein Jag, GO:0003723, cmr|LMOf2365_2843, cmr|LMOh7858_3116, Human antigen R (HuR) is a widely expressed RNA binding protein that interacts with specific AU-rich domains in target mRNAs and exerts av A Gormand · 2014 · Citerat av 18 — cAMP-response element-binding protein (CREB) is required for the and the mRNA expression of adipogenic transcription factors Cebpa, Human antigen R (HuR) is an RNA-binding protein that regulates the stability, translation, and nucleus-to-cytoplasm shuttling of its target mRNAs. While HuR is normally localized within the nucleus, it has been shown that HuR binds mRNAs in the nucleus and then escorts the mRNAs to the cytoplasm where HuR protects them from degradation. ELAV-like protein 1 or HuR is a protein that in humans is encoded by the ELAVL1 gene.
What Is New? The cardiac sodium channel α‐subunit mRNA is upregulated by the transcription factor myocyte enhancer factor‐2C (MEF2C). MEF2C is upregulated by binding of RNA stabilizing protein, HuR (alias ELAVL1). The association of HuR protein and MEF2C mRNA protects MEF2C mRNA from degradation. Human antigen R (HuR) is a member of the Hu family of RNA-binding proteins.
HuR was known to stabilize many of these mRNAs and/or modulated their translation, but the molecular processes by which HuR affected the fate of target mRNAs was largely unknown. The mammalian RNA-binding protein (RBP) HuR associates with numerous mRNAs encoding proteins with roles in cell division, cell survival, immune response, and differentiation. HuR was known to stabilize many of these mRNAs and/or modulated their translation, but the molecular processes by which HuR affected the fate of target mRNAs was largely unknown.
The 3′ UTR of p53 was found to be a target of the RNA-binding protein HuR in a UVC-dependent manner in vitro and in vivo. HuR-overexpressing RKO cells displayed elevated p53 levels, whereas cells expressing reduced HuR showed markedly diminished p53 abundance and p53 translation.
Gene ID (Entrez), 100526737. Name, RNA-binding protein 14 Protein. Purity, Greater than 90% as determined by av MG till startsidan Sök — Hur många som insjuknar i Welanders distala myopati varje år varierar av (kodar för) TIA1 cytotoxic granule associated RNA binding protein.
2018-04-20 · METHODS AND RESULTS: Herein, we show that, as evidenced by ribonucleoprotein immunoprecipitation assay, RNA binding protein Hu antigen R/ELAV like RNA binding protein 1 (HuR/ELAVL1) and myocyte enhancer factor-2C (MEF2C) transcription factor mRNA are associated. HuR positively regulated transcription factor MEF2C mRNA expression by protecting its mRNA from degradation.
Crossref, Medline, Google Scholar Growing evidence shows that cancer cells use mRNA-binding proteins and miRNAs to posttranscriptionally regulate signaling pathways to adapt to harsh tumor microenvironments. In ovarian cancer, cytoplasmic accumulation of mRNA-binding protein HuR (ELAVL1) is associated with poor prognosis. In this study, we observed high HuR expression in ovarian cancer cells compared with ovarian primary cells RNA-binding proteins represent an emerging class of proteins with a role in renal dysfunction. We show that activation of the RNA-binding protein Hu antigen R (HuR) is increased in glomerulosclerosis not only in anti-Thy 1.1 nephritis model but also in varied human glomerular diseases. 2021-04-04 · RNA-binding protein HuR regulates translation of vitamin D receptor modulating rapid epithelial restitution after wounding. Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis. Human antigen R protein modulates vascular endothelial growth factor expression in human corneal epithelial cells under hypoxia.
Over the past decade, this ubiquitously expressed protein has been extensively investigated in cancer research because it is involved in the regulation of mRNA stability and translation in many cell types. RNA-binding proteins (RBPs) are key players in post-transcriptional events. The combination of versatility of their RNA-binding domains with structural flexibility enables RBPs to control the metabolism of a large array of transcripts. Perturbations in RBP–RNA networks activity have been causally associated with cancer development, but the rational framework describing these contributions
HuR, an RNA-binding protein, post-transcriptionally regulates nearly 4% of encoding proteins implicated in cell survival. Here we show that HuR is required for the efficacy of chemotherapies in
To investigate the effects of RNA‐binding proteins cold‐inducible RNA binding protein (CIRP) and human antigen R (HuR) on expression of Claudin1 and mucosal barrier function in ulcerative colitis (UC). The clinical specimens of UC patients and healthy volunteers were collected.
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HuR-overexpressing RKO cells displayed elevated p53 levels, whereas cells expressing reduced HuR showed markedly diminished p53 abundance and p53 translation.
Turner and colleagues demonstrate that HuR serves a critical role in thymus-independent antigen responses by regulating
Protein 1, ELAVL1) is an RNA-binding protein,26 it may effect the stabilization of mRNAs so as to regulate their expression and is in-volved in various biological progresses. Recent studies showed that HuR is related to autophagy 26; also, HuR is regarded as a crucial metabolic regulator of diabetes,27 which implied that HuR may play
The 3′ UTR of p53 was found to be a target of the RNA-binding protein HuR in a UVC-dependent manner in vitro and in vivo. HuR-overexpressing RKO cells displayed elevated p53 levels, whereas cells expressing reduced HuR showed markedly diminished p53 abundance and p53 translation.
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The RNA-binding protein HuR associates with the p53 mRNA, as reported previously, and with the NPM mRNA, computationally predicted to be a target of HuR. Here, we show that HuR binds the NPM and p53 3′-untranslated regions and stabilizes these mRNAs in polyamine-depleted intestinal epithelial cells.
The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. One of its best-known functions is to stabilize mRNAs in order to regulate gene expression.
May 1, 2011 The RNA-Binding Protein HuR Promotes Glioma Growth and Treatment Resistance. Natalia Filippova, Xiuhua Yang, Yimin Wang, G. Yancey
The RNA-binding protein, HuR, associates with the HuR mRNA, but the consequences of this interaction are unknown. Here, we use human The RNA Club Stockholm serves a platform for scientific exchange for people will give a seminar on RNA-binding proteins tomorrow Tuesday at SciLifeLab av vilka sjukdomar, men hur många av oss vill egentligen ha den informationen? Accession Number, NP_001185765.1.
In ovarian cancer, cytoplasmic accumulation of mRNA-binding protein HuR (ELAVL1) is associated with poor prognosis. In this study, we observed high HuR expression in ovarian cancer cells compared with ovarian primary cells RNA-binding proteins represent an emerging class of proteins with a role in renal dysfunction. We show that activation of the RNA-binding protein Hu antigen R (HuR) is increased in glomerulosclerosis not only in anti-Thy 1.1 nephritis model but also in varied human glomerular diseases.